Axitinib-Impurities | Pharmaffiliates

axitinib

Axitinib is an indazole derivative. It is most commonly marketed under the name Inlyta® and is available in oral formulations._x000D_ Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3).7. Reference standards of Axitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => (E)-N-Methyl-2-((1-(2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide
    [catalogue_number] => PA 28 45550
    [category_ids] => ,80,81,78,70,82,88,
    [chemical_name] => 
    [weight] => 491.61
    [form] => C29H25N5OS
    [cas] => 1443118-72-6
    [pslug] => 1443118-72-6-e-n-methyl-2-1-2-pyridin-2-yl-ethyl-3-2-pyridin-2-yl-vinyl-1h-indazol-6-yl-thio-benzamide-pa2845550
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PA 28 45550

(E)-N-Methyl-2-((1-(2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide


  • Catalogue No.:PA 28 45550

  • CAS :

    1443118-72-6

  • Molecular Formula : C29H25N5OS

  • Molecular Weight : 491.61

stdClass Object
(
    [pname] => Axitinib N-Glucuronide
    [catalogue_number] => PA 28 45560
    [category_ids] => ,80,81,78,70,82,88,
    [chemical_name] => 
    [weight] => 562.59
    [form] => C28H26N4O7S
    [cas] => NA
    [pslug] => axitinib-n-glucuronide-pa2845560
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PA 28 45560

Axitinib N-Glucuronide


  • Catalogue No.:PA 28 45560

  • CAS :

    NA

  • Molecular Formula : C28H26N4O7S

  • Molecular Weight : 562.59

stdClass Object
(
    [pname] => Axitinib Sulfone Impurity
    [catalogue_number] => PA 28 45570
    [category_ids] => ,80,81,78,70,82,88,
    [chemical_name] => 
    [weight] => 418.47
    [form] => C22H18N4O3S
    [cas] => 1348536-59-3
    [pslug] => 1348536-59-3-axitinib-sulfone-impurity-pa2845570
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PA 28 45570

Axitinib Sulfone Impurity


  • Catalogue No.:PA 28 45570

  • CAS :

    1348536-59-3

  • Molecular Formula : C22H18N4O3S

  • Molecular Weight : 418.47

stdClass Object
(
    [pname] => 2-(1H-Indazol-6-ylsulfanyl)-N-methylbenzamide
    [catalogue_number] => PA 28 45580
    [category_ids] => ,80,81,78,70,82,88,
    [chemical_name] => 
    [weight] => 283.34
    [form] => C15H13N3OS
    [cas] => 944835-85-2
    [pslug] => 944835-85-2-2-1h-indazol-6-ylsulfanyl-n-methylbenzamide-pa2845580
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PA 28 45580

2-(1H-Indazol-6-ylsulfanyl)-N-methylbenzamide


  • Catalogue No.:PA 28 45580

  • CAS :

    944835-85-2

  • Molecular Formula : C15H13N3OS

  • Molecular Weight : 283.34

stdClass Object
(
    [pname] => 2-((3-Iodo-2H-indazol-6-yl)thio)-N-methylbenzamide
    [catalogue_number] => PA 28 45590
    [category_ids] => ,80,81,78,70,82,88,
    [chemical_name] => 
    [weight] => 409.24
    [form] => C15H12IN3OS
    [cas] => 885126-34-1
    [pslug] => 885126-34-1-2-3-iodo-2h-indazol-6-yl-thio-n-methylbenzamide-pa2845590
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PA 28 45590

2-((3-Iodo-2H-indazol-6-yl)thio)-N-methylbenzamide


  • Catalogue No.:PA 28 45590

  • CAS :

    885126-34-1

  • Molecular Formula : C15H12IN3OS

  • Molecular Weight : 409.24

stdClass Object
(
    [pname] => Dehydro Axitinib
    [catalogue_number] => PA 28 45600
    [category_ids] => ,80,81,78,70,82,88,
    [chemical_name] => 
    [weight] => 388.49
    [form] => C22H20N4OS
    [cas] => NA
    [pslug] => dehydro-axitinib-pa2845600
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PA 28 45600

Dehydro Axitinib


  • Catalogue No.:PA 28 45600

  • CAS :

    NA

  • Molecular Formula : C22H20N4OS

  • Molecular Weight : 388.49

stdClass Object
(
    [pname] => Axitinib Amide Impurity
    [catalogue_number] => PA 28 45620
    [category_ids] => ,80,81,78,70,82,88,
    [chemical_name] => 
    [weight] => 372.44
    [form] => C21H16N4OS
    [cas] => NA
    [pslug] => axitinib-amide-impurity-pa2845620
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PA 28 45620

Axitinib Amide Impurity


  • Catalogue No.:PA 28 45620

  • CAS :

    NA

  • Molecular Formula : C21H16N4OS

  • Molecular Weight : 372.44

stdClass Object
(
    [pname] => Axitinib N-THP Impurity
    [catalogue_number] => PA 28 45640
    [category_ids] => 81,88,80,70,78,82
    [chemical_name] => 
    [weight] => 470.59
    [form] => C27H26N4O2S
    [cas] => NA
    [pslug] => axitinib-n-thp-impurity-pa2845640
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PA 28 45640

Axitinib N-THP Impurity


  • Catalogue No.:PA 28 45640

  • CAS :

    NA

  • Molecular Formula : C27H26N4O2S

  • Molecular Weight : 470.59

stdClass Object
(
    [pname] => 2-((1-Acetyl-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide
    [catalogue_number] => PA 28 45670
    [category_ids] => ,79,80,71,88,
    [chemical_name] => 
    [weight] => 341.38
    [form] => C17H15N3O3S
    [cas] => NA
    [pslug] => 2-1-acetyl-1h-indazol-6-yl-sulfinyl-n-methylbenzamide-pa2845670
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PA 28 45670

2-((1-Acetyl-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide


  • Catalogue No.:PA 28 45670

  • CAS :

    NA

  • Molecular Formula : C17H15N3O3S

  • Molecular Weight : 341.38

stdClass Object
(
    [pname] => 2-((1H-Indazol-6-yl)sulfinyl)-N-methylbenzamide
    [catalogue_number] => PA 28 45680
    [category_ids] => ,79,80,71,88,78,
    [chemical_name] => 
    [weight] => 299.35
    [form] => C15H13N3O2S
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PA 28 45680

2-((1H-Indazol-6-yl)sulfinyl)-N-methylbenzamide


  • Catalogue No.:PA 28 45680

  • CAS :

    NA

  • Molecular Formula : C15H13N3O2S

  • Molecular Weight : 299.35

stdClass Object
(
    [pname] => 2-((3-Iodo-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide
    [catalogue_number] => PA 28 45700
    [category_ids] => ,79,80,71,88,78,
    [chemical_name] => 
    [weight] => 425.24
    [form] => C15H12IN3O2S
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PA 28 45700

2-((3-Iodo-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide


  • Catalogue No.:PA 28 45700

  • CAS :

    NA

  • Molecular Formula : C15H12IN3O2S

  • Molecular Weight : 425.24