Axitinib is an indazole derivative. It is most commonly marketed under the name Inlyta® and is available in oral formulations._x000D_ Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3).7. Reference standards of Axitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object ( [pname] => (E)-N-Methyl-2-((1-(2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide [catalogue_number] => PA 28 45550 [category_ids] => ,80,81,78,70,82,88, [chemical_name] => [weight] => 491.61 [form] => C29H25N5OS [cas] => 1443118-72-6 [pslug] => 1443118-72-6-e-n-methyl-2-1-2-pyridin-2-yl-ethyl-3-2-pyridin-2-yl-vinyl-1h-indazol-6-yl-thio-benzamide-pa2845550 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 28 45550
CAS :
Molecular Formula : C29H25N5OS
Molecular Weight : 491.61
stdClass Object ( [pname] => Axitinib N-Glucuronide [catalogue_number] => PA 28 45560 [category_ids] => ,70,78,80,81,82,88,95, [chemical_name] => [weight] => 562.59 [form] => C28H26N4O7S [cas] => NA [pslug] => axitinib-n-glucuronide-pa2845560 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 28 45560
Molecular Formula : C28H26N4O7S
Molecular Weight : 562.59
stdClass Object ( [pname] => Axitinib Sulfone Impurity [catalogue_number] => PA 28 45570 [category_ids] => ,80,81,78,70,82,88, [chemical_name] => [weight] => 418.47 [form] => C22H18N4O3S [cas] => 1348536-59-3 [pslug] => 1348536-59-3-axitinib-sulfone-impurity-pa2845570 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 28 45570
Molecular Formula : C22H18N4O3S
Molecular Weight : 418.47
stdClass Object ( [pname] => 2-(1H-Indazol-6-ylsulfanyl)-N-methylbenzamide [catalogue_number] => PA 28 45580 [category_ids] => ,80,81,78,70,82,88, [chemical_name] => [weight] => 283.34 [form] => C15H13N3OS [cas] => 944835-85-2 [pslug] => 944835-85-2-2-1h-indazol-6-ylsulfanyl-n-methylbenzamide-pa2845580 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 28 45580
Molecular Formula : C15H13N3OS
Molecular Weight : 283.34
stdClass Object ( [pname] => 2-((3-Iodo-2H-indazol-6-yl)thio)-N-methylbenzamide [catalogue_number] => PA 28 45590 [category_ids] => ,80,81,78,70,82,88, [chemical_name] => [weight] => 409.24 [form] => C15H12IN3OS [cas] => 885126-34-1 [pslug] => 885126-34-1-2-3-iodo-2h-indazol-6-yl-thio-n-methylbenzamide-pa2845590 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 28 45590
Molecular Formula : C15H12IN3OS
Molecular Weight : 409.24
stdClass Object ( [pname] => Dehydro Axitinib [catalogue_number] => PA 28 45600 [category_ids] => ,80,81,78,70,82,88, [chemical_name] => [weight] => 388.49 [form] => C22H20N4OS [cas] => 2749797-54-2 [pslug] => 2749797-54-2-dehydro-axitinib-pa2845600 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 28 45600
Molecular Formula : C22H20N4OS
Molecular Weight : 388.49
stdClass Object ( [pname] => Axitinib Amide Impurity [catalogue_number] => PA 28 45620 [category_ids] => ,80,81,78,70,82,88, [chemical_name] => [weight] => 372.44 [form] => C21H16N4OS [cas] => 319462-41-4 [pslug] => 319462-41-4-axitinib-amide-impurity-pa2845620 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 28 45620
Molecular Formula : C21H16N4OS
Molecular Weight : 372.44
stdClass Object ( [pname] => Axitinib N-THP Impurity [catalogue_number] => PA 28 45640 [category_ids] => 81,88,70,78,82,80 [chemical_name] => [weight] => 470.59 [form] => C27H26N4O2S [cas] => 885126-35-2 [pslug] => 885126-35-2-axitinib-n-thp-impurity-pa2845640 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 28 45640
Molecular Formula : C27H26N4O2S
Molecular Weight : 470.59
stdClass Object ( [pname] => 2-((3-Iodo-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide [catalogue_number] => PA 28 45700 [category_ids] => ,79,80,71,88,78, [chemical_name] => [weight] => 425.24 [form] => C15H12IN3O2S [cas] => 1443118-71-5 [pslug] => 1443118-71-5-2-3-iodo-1h-indazol-6-yl-sulfinyl-n-methylbenzamide-pa2845700 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 28 45700
Molecular Formula : C15H12IN3O2S
Molecular Weight : 425.24
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