acarbose and its Impurities
Acarbose is composed of anacarviosin moiety with a maltose at the reducing terminus. It is an anti-diabetic drug. It is a starch blocker and inhibits alpha glucosidase, that releases glucose from larger carbohydrates. Reference standards of Acarbose API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Acarbose - Impurity A
O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-enyl]amino]-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-D-arabino-hex-2-ulopyranose
Catalogue No.:PA 01 07010
CAS :
1013621-79-8
Molecular Formula : C25H43NO18
Molecular Weight : 645.6
Acarbose - Impurity B
(1R,4R,5S,6R)-4,5,6-Trihydroxy-2-(hydroxymethyl)cyclohex-2-enyl 4-O-[4,6- dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2- enyl]amino]-α-D-glucopyranosyl]-α-D-glucopyranoside
Catalogue No.:PA 01 07020
CAS :
1220983-54-9
Molecular Formula : C26H43NO17
Molecular Weight : 641.62
Acarbose - Impurity H
O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-enyl]amino]-α-D-glucopyranosyl-(1→4)-O-6-deoxy-α-D-glucopyranosyl-(1→4)-D-glucopyranose
Catalogue No.:PA 01 07080
CAS :
196944-81-7
Molecular Formula : C25H43NO17
Molecular Weight : 629.6
N-((2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6R)-4,5-Dihydroxy-2-(hydroxymethyl)-6-(((2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-4,5-dihydroxy-2-methyltetrahydro-2H-pyran-3-yl)-N-((1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl)nitrous Amide
N-((2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6R)-4,5-Dihydroxy-2-(hydroxymethyl)-6-(((2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-4,5-dihydroxy-2-methyltetrahydro-2H-pyran-3-yl)-N-((1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl)nitrous Amide
Catalogue No.:PA 01 0071002
CAS :
NA
Molecular Formula : C25H42N2O19
Molecular Weight : 674.61
