Apixaban, sold under the trade name Eliquis among others, is an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with nonvalvular atrial fibrillation.. Reference standards of Apixaban API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
Apixaban
Catalogue No.:PA 28 11000
CAS :
Molecular Formula : C25H25N5O4
Molecular Weight : 459.50
O-Desmethyl Apixaban
Catalogue No.:PA 28 11510
Molecular Formula : C24H23N5O4
Molecular Weight : 445.47
O-Desmethyl Apixaban Sulfate
Catalogue No.:PA 28 11520
Molecular Formula : C24H23N5O7S
Molecular Weight : 525.53
Hydroxy Apixaban
Catalogue No.:PA 28 11530
Molecular Formula : C25H25N5O5
Molecular Weight : 475.5
Hydroxy O-Demethyl Apixaban
Catalogue No.:PA 28 11540
Molecular Formula : C24H23N5O5
Molecular Weight : 461.47
Hydroxy O-Demethyl Apixaban Sulfate
Catalogue No.:PA 28 11550
Molecular Formula : C24H23N5O8S
Molecular Weight : 541.53
3-Carbamoyl-1-(4-methoxyphenyl)-4-(2-(4-(2-oxopiperidin-1-yl)phenylamino)ethyl)-1H-pyrazole-5-carboxylic Acid
Catalogue No.:PA 28 11560
Molecular Formula : C25H27N5O5
Molecular Weight : 477.51
Apixaban Carboxylic Acid Impurity
Catalogue No.:PA 28 11570
Molecular Formula : C25H24N4O5
Molecular Weight : 460.48
6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic Acid
Catalogue No.:PA 28 11580
Molecular Formula : C20H18N4O4
Molecular Weight : 378.38
Apixaban Amino Acid Impurity
Catalogue No.:PA 28 11590
Molecular Weight : 477.52
Methyl 6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Catalogue No.:PA 28 11600
Molecular Formula : C21H20N4O4
Molecular Weight : 392.41
Apixaban Methyl Ester Impurity
Catalogue No.:PA 28 11610
Molecular Formula : C26H26N4O5
Molecular Weight : 474.51
Methyl 5-((4-(3-Carbamoyl-1-(4-methoxyphenyl)-7-oxo-4,5-dihydro-1H-pyrazolo[3,4-c]pyridin-6(7H)-yl)phenyl)amino)pentanoate
Catalogue No.:PA 28 11620
Molecular Formula : C26H29N5O5
Molecular Weight : 491.54
Apixaban Dehydro Impurity
Catalogue No.:PA 28 11630
Molecular Formula : C25H23N5O4
Molecular Weight : 457.48
Apixaban Carboxylic Acid O-Desmethyl Impurity
Catalogue No.:PA 28 11640
Molecular Formula : C24H22N4O5
Molecular Weight : 446.46
Apixaban Chloro Impurity
Catalogue No.:PA 28 11650
Molecular Formula : C24H22ClN5O3
Molecular Weight : 463.92
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Catalogue No.:PA 28 11660
Molecular Formula : C27H28N4O5
Molecular Weight : 488.54
Apixaban Isopropyl Ester Impurity
Catalogue No.:PA 28 11670
Molecular Formula : C28H30N4O5
Molecular Weight : 502.56
6-(4-((5-Amino-5-oxopentyl)amino)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Catalogue No.:PA 28 11680
Molecular Formula : C25H28N6O4
Molecular Weight : 476.53
1-(4-Methoxyphenyl)-6-(4-(5-methyl-2-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Catalogue No.:PA 28 11690
Molecular Formula : C26H27N5O4
Molecular Weight : 473.52
1-(4-Methoxyphenyl)-6-(4-(2-methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Catalogue No.:PA 28 11700
(E)-Ethyl 2-(2-(4-methoxyphenyl)hydrazono)propanoate
Catalogue No.:PA 28 11710
Molecular Formula : C12H16N2O3
Molecular Weight : 236.27
3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Catalogue No.:PA 28 11720
Molecular Formula : C11H9ClN2O3
Molecular Weight : 252.65
5-Chloro-4-methylpentanoyl Chloride
Catalogue No.:PA 28 11730
Molecular Formula : C6H10Cl2O
Molecular Weight : 169.05
5-Chloro-hexanoyl Chloride
Catalogue No.:PA 28 11740
1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxoazepan-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Catalogue No.:PA 28 11750
Molecular Weight : 473.53
1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopyrrolidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Catalogue No.:PA 28 11760
6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Catalogue No.:PA 28 11770
Molecular Formula : C20H19N5O3
Molecular Weight : 377.4
1-(4-Methoxyphenyl)-3-(morpholine-4-carbonyl)-6-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydro-1H-pyrazolo[3,4-c]pyridin-7(4H)-one
Catalogue No.:PA 28 11780
Molecular Formula : C29H31N5O5
Molecular Weight : 529.59
(E)-1,2-Bis(4-(3-carbamoyl-1-(4-methoxyphenyl)-7-oxo-4,5-dihydro-1H-pyrazolo[3,4-c]pyridin-6(7H)-yl)phenyl)diazene oxide
Catalogue No.:PA 28 11790
Molecular Formula : C40H34N10O7
Molecular Weight : 766.76
5-Chloro-N-(4-(3-morpholino-2-oxo-5,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide
Catalogue No.:PA 28 11800
Molecular Formula : C20H26ClN3O3
Molecular Weight : 391.89
Ethyl 6-(4-(5-chloropentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Catalogue No.:PA 28 11810
Molecular Formula : C27H29ClN4O5
Molecular Weight : 525
(Z)-Ethyl 2-chloro-2-(2-(3-methoxyphenyl)hydrazono)acetate
Catalogue No.:PA 28 11820
Molecular Formula : C11H13ClN2O3
Molecular Weight : 256.69
N-Formyl-1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Catalogue No.:PA 28 11830
Molecular Formula : C26H25N5O5
Molecular Weight : 487.51
Ethyl-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate
Catalogue No.:PA 28 11840
3-(Morpholinyl)-N-(4-nitrophenyl)-5,6-dihydropyridin-2-one
Catalogue No.:PA 28 11850
Molecular Formula : C15H17N3O4
Molecular Weight : 303.31
5-Methyltetrahydro-2H-pyran-2-one
Catalogue No.:PAI 01 012010
Molecular Formula : C6H10O2
Molecular Weight : 114.14
5-Hydroxy-4-methylpentanoic acid
Catalogue No.:PAI 01 012020
Molecular Formula : C6H12O3
Molecular Weight : 132.16
Apixaban Dimer
Catalogue No.:PA 28 11890
Molecular Formula : C40H34N10O6
Molecular Weight : 750.78
Apixaban N-Oxide Dimer
Catalogue No.:PA 28 11900
Molecular Weight : 766.78
7-Oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Catalogue No.:PA 28 11910
Molecular Formula : C24H23N5O3
Molecular Weight : 429.48
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
Catalogue No.:PA 28 11920
Molecular Formula : C20H25N3O3
Molecular Weight : 355.44
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)pyridin-2(1H)-one
Catalogue No.:PA 28 0111000
Molecular Formula : C20H23N3O3
Molecular Weight : 353.42
Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
Catalogue No.:PA 28 0111001
3-Morpholino-5,6-dihydropyridin-2(1H)-one
Catalogue No.:PA 28 0111002
Molecular Formula : C9H14N2O2
Molecular Weight : 182.22
1-(4-Iodophenyl)piperidin-2-one
Catalogue No.:PA 28 0111003
Molecular Formula : C11H12INO
Molecular Weight : 301.13
Ethyl 6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Catalogue No.:PA 28 0111004
Molecular Formula : C22H22N4O4
Molecular Weight : 406.44
6-(4-(5-chloropentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Catalogue No.:PA 28 0111005
Molecular Formula : C25H26ClN5O4
Molecular Weight : 495.96
1-(4-(5-methyl-2-oxopiperidin-1-yl)phenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
Catalogue No.:PA 28 0111006
Molecular Formula : C21H27N3O3
Molecular Weight : 369.47
1-(4-(2-methyl-6-oxopiperidin-1-yl)phenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
Catalogue No.:PA 28 0111007
3-Chloro-1-(4-nitrophenyl)piperidin-2-one
Catalogue No.:PA 28 0111008
Molecular Formula : C11H11ClN2O3
Molecular Weight : 254.67
(Z)-1,2-Bis(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)diazene 1-oxide
Catalogue No.:PA 28 0111009
Molecular Formula : C30H34N6O5
Molecular Weight : 558.64
(E)-1,1'-(Diazene-1,2-diylbis(4,1-phenylene))bis(3-morpholino-5,6-dihydropyridin-2(1H)-one)
Catalogue No.:PA 28 0111010
Molecular Formula : C30H34N6O4
Molecular Weight : 542.64
Ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Catalogue No.:PA 28 0111011
Molecular Formula : C22H20N4O6
Molecular Weight : 436.42
3-Chloro-1-(2-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Catalogue No.:PA 28 0111012
1-(4-Methoxyphenyl)-6-(4-(2-methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide
Catalogue No.:PA 28 0111013
Molecular Formula : C27H28N4O4
Molecular Weight : 472.55
Diethyl 1-(4-methoxyphenyl)-1H-1,2,4-triazole-3,5-dicarboxylate
Catalogue No.:PA 28 0111014
Molecular Formula : C15H17N3O5
Molecular Weight : 319.32
(E)-Diethyl 6,6’-(diazene-1,2-diylbis(4,1-phenylene))bis(1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate)
Catalogue No.:PA 28 0111015
Molecular Formula : C44H40N8O8
Molecular Weight : 808.85
(Z)-1,2-Bis(4-(3-(ethoxycarbonyl)-1-(4-methoxyphenyl)-7-oxo-4,5-dihydro-1H-pyrazolo[3,4-c]pyridin-6(7H)-yl)phenyl)diazene oxide
Catalogue No.:PA 28 0111016
Molecular Formula : C44H40N8O9
Molecular Weight : 824.85
2-Hydroxyethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Catalogue No.:PA 28 0111017
Molecular Formula : C27H28N4O6
Molecular Weight : 504.54
1-(4-Ethoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Catalogue No.:PA 28 0111018
Methyl 6-(4-(5-chloropentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Catalogue No.:PA 28 0111019
Molecular Formula : C26H27ClN4O5
Molecular Weight : 510.98
Ethyl 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Catalogue No.:PA 28 0111022
Molecular Formula : C26H25ClN4O4
Molecular Weight : 492.96
Ethyl 2-(5-hydroxy-6-oxo-1-(4-(2-oxopiperidin-1-yl)phenyl)-1,2,3,6-tetrahydropyridin-4-yl)-2-oxoacetate
Catalogue No.:PA 28 0111020
Molecular Formula : C20H22N2O6
Molecular Weight : 386.4
Ethyl 1-(4-methoxyphenyl)-7a-morpholino-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Catalogue No.:PA 28 0111021
Molecular Formula : C31H37N5O6
Molecular Weight : 575.67
3,5-Dichloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Catalogue No.:PA 28 0111037
Molecular Formula : C11H8Cl2N2O3
Molecular Weight : 287.1
Ethyl 2-(2-(4-methoxyphenyl)hydrazinyl)-2-oxoacetate
Catalogue No.:PA 28 0111024
Molecular Formula : C11H14N2O4
Molecular Weight : 238.24
(E)-1,3-Bis(4-methoxyphenyl)triaz-1-ene
Catalogue No.:PA 28 0111025
Molecular Formula : C14H15N3O2
Molecular Weight : 257.29
Ethyl 1-(4-(benzyloxy)phenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Catalogue No.:PA 28 0111026
Molecular Formula : C33H32N4O5
Molecular Weight : 564.64
1-(4-(Benzyloxy)phenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Catalogue No.:PA 28 0111027
Molecular Formula : C31H29N5O4
Molecular Weight : 535.6
1-(2-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
Catalogue No.:PA 28 0111028
Molecular Formula : C15H19N3O2
Molecular Weight : 273.15
Ethyl 5-(morpholin-4-yl)pentanoate
Catalogue No.:PA 28 0111029
Molecular Formula : C11H21NO3
Molecular Weight : 215.29
3-Morpholino-1-(4-nitrophenyl)piperidin-2-one
Catalogue No.:PA 28 0111030
Molecular Formula : C15H19N3O4
Molecular Weight : 305.33
1-(4-Aminophenyl)-3-morpholinopiperidin-2-one
Catalogue No.:PA 28 0111031
Molecular Formula : C15H21N3O2
Molecular Weight : 275.35
1,1'-(1,4-Phenylene)bis(piperidin-2-one)
Catalogue No.:PA 28 0111032
Molecular Formula : C16H20N2O2
Molecular Weight : 272.35
1-(4-(2-Oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
Catalogue No.:PA 28 0111033
Molecular Formula : C16H18N2O2
Molecular Weight : 270.33
5-Morpholinopentanamide
Catalogue No.:PA 28 0111034
Molecular Formula : C9H18N2O2
Molecular Weight : 186.26
1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Catalogue No.:PA 28 0111035
Molecular Formula : C20H17N5O5
Molecular Weight : 407.39
1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
Catalogue No.:PA 28 0111036
Molecular Weight : 273.34
Potassium 3-carbamoyl-1-(4-methoxyphenyl)-4-(2-((4-(2-oxopiperidin-1-yl)phenyl)amino)ethyl)-1H-pyrazole-5-carboxylate
Catalogue No.:PA 28 0111023
Molecular Formula : C25H26KN5O5
Molecular Weight : 515.61
5-((4-(3-Carbamoyl-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)phenyl)amino)pentanoic-1-14C acid
Catalogue No.:PA STI 089014
Molecular Formula : C2414CH27N5O5
Molecular Weight : 479.51
Ethyl (Z)-2-chloro-2-(2-(2-methoxyphenyl)hydrazono)acetate
Catalogue No.:PA 28 0111038
4-Chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)butanamide
Catalogue No.:PA 28 0111039
Molecular Formula : C19H24ClN3O3
Molecular Weight : 377.87
Ethyl 6-(4-(5-bromopentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Catalogue No.:PA 28 0111040
Molecular Formula : C27H29BrN4O5
Molecular Weight : 569.46
5-Chloro-N-(4-nitrophenyl)pentanamide
Catalogue No.:PA 28 0111041
Methyl 5-chloropentanoate
Catalogue No.:PA 28 0111042
Molecular Formula : C6H11ClO2
Molecular Weight : 150.6
Ethyl 5-Chloropentanoate
Catalogue No.:PA 28 0111043
Molecular Formula : C7H13ClO2
Molecular Weight : 164.63
1-(4-Aminophenyl)-3-morpholinopyridin-2(1H)-one
Catalogue No.:PA 28 0111044
Molecular Formula : C15H17N3O2
Molecular Weight : 271.32
1-(2-Aminophenyl)-3-morpholinopiperidin-2-one
Catalogue No.:PA 28 0111045
Ethyl (Z)-2-chloro-2-(2-(4-methoxyphenyl)-2-nitrosohydrazono)acetate
Catalogue No.:PA 28 0111046
Molecular Formula : C11H12ClN3O4
Molecular Weight : 285.68
Ethyl 6-(4-(5-chloro-N-nitrosopentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Catalogue No.:PA 28 0111047
Molecular Formula : C27H28ClN5O6
Molecular Weight : 554
3-Morpholino-1-(4-nitrophenyl)pyridin-2(1H)-one
Catalogue No.:PA 28 0111048
Molecular Formula : C15H15N3O4
Molecular Weight : 301.3
N-Nitroso Apixaban Amino Acid Impurity
Catalogue No.:PA 28 0111049
Molecular Formula : C25H26N6O6
Molecular Weight : 506.52
6-Chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)-N-nitrosohexanamide
Catalogue No.:PA 28 0111050
Molecular Formula : C21H27ClN4O4
Molecular Weight : 434.92
Apixaban Carboxylic Acid Impurity Sodium Salt
Catalogue No.:PA 28 0111051
Molecular Formula : C25H23N4NaO5
Molecular Weight : 482.47
Apixaban Carboxylic Acid Impurity Calcium Salt
Catalogue No.:PA 28 0111052
Molecular Formula : C50H46CaN8O10
Molecular Weight : 959.04
Apixaban Carboxylic Acid Impurity Potassium Salt
Catalogue No.:PA 28 0111053
Molecular Formula : C25H23KN4O5
Molecular Weight : 498.58
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)piperidin-2-one
Catalogue No.:PA 28 0111054
Molecular Formula : C20H27N3O3
Molecular Weight : 357.45
Ethyl 2-chloro-2-(2-(2-methoxyphenyl)hydrazono)acetate
Catalogue No.:PA 28 0111055
1-(4-Aminophenyl)-3-chloro-5,6-dihydropyridin-2(1H)-one
Catalogue No.:PA 28 0111057
Molecular Formula : C11H11ClN2O
Molecular Weight : 222.67
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