irinotecan and its Impurities
Irinotecan main use is in colon cancer, in particular, in combination with other chemotherapy agents. This includes the regimen FOLFIRI, which consists of infusional 5-fluorouracil, leucovorin, and irinotecan. It is sold under the brand name Camptosar. Reference standards of Irinotecan API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
4-Ethyl-4-hydroxy-11-isopropyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate;
4-Ethyl-4-hydroxy-11-isopropyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate;
Catalogue No.:PA 09 16570
CAS :
NA
Molecular Formula : C34H40N4O6
Molecular Weight : 600.7
(S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline 6-oxide
(S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline 6-oxide
Catalogue No.:PA 09 16590
CAS :
86639-51-2
Molecular Formula : C22H20N2O5
Molecular Weight : 392.41
Irinotecan Related Compound A ((S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quino (1347610)
Irinotecan Related Compound A ((S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quino (1347610)
Catalogue No.:PA USP1347610
CAS :
19685-09-7
Molecular Formula : NA
Molecular Weight : NA
Irinotecan Related Compound B ((S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b] (1347631)
Irinotecan Related Compound B ((S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b] (1347631)
Catalogue No.:PA USP1347631
CAS :
86639-52-3
Molecular Formula : NA
Molecular Weight : NA
Irinotecan Related Compound C (11-Ethyl-4-hydroxy-4-methyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyran (1347642)
Irinotecan Related Compound C (11-Ethyl-4-hydroxy-4-methyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyran (1347642)
Catalogue No.:PA USP1347642
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA
Irinotecan Related Compound D ((R)-9-[(1,4'-Bipiperidine)-1'-carbonyloxy]-4,11-diethyl-3,4,12,14-te (1347653)
Irinotecan Related Compound D ((R)-9-[(1,4'-Bipiperidine)-1'-carbonyloxy]-4,11-diethyl-3,4,12,14-te (1347653)
Catalogue No.:PA USP1347653
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA
Irinotecan Related Compound E ((S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quin (1347664)
Irinotecan Related Compound E ((S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quin (1347664)
Catalogue No.:PA USP1347664
CAS :
78287-27-1
Molecular Formula : NA
Molecular Weight : NA
(S)-8-Bromo-4,11-diethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione
(S)-8-Bromo-4,11-diethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione
Catalogue No.:PAI 09 008010
CAS :
NA
Molecular Formula : C22H19BrN2O5
Molecular Weight : 471.31
(S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 2'-ethoxy-[1,4'-bipiperidine]-1'-carboxylate
(S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 2'-ethoxy-[1,4'-bipiperidine]-1'-carboxylate
Catalogue No.:PA 09 0151001
CAS :
NA
Molecular Formula : C35H42N4O7
Molecular Weight : 630.74
(4S)-4,11-Diethyl-4,9,12-trihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione
(4S)-4,11-Diethyl-4,9,12-trihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione
Catalogue No.:PA 09 0151002
CAS :
200619-21-2
Molecular Formula : C22H20N2O6
Molecular Weight : 408.41
(S)-12-Ethyl-8-(hydroxymethyl)-7-(1-hydroxypropyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-2-yl [1,4'-bipiperidine]-1'-carboxylate
(S)-12-Ethyl-8-(hydroxymethyl)-7-(1-hydroxypropyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-2-yl [1,4'-bipiperidine]-1'-carboxylate
Catalogue No.:PA 09 0151006
CAS :
185304-41-0
Molecular Formula : C32H40N4O5
Molecular Weight : 560.7
Sodium (S)-2-(12-ethyl-8-(hydroxymethyl)-2-oxido-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)-2-hydroxybutanoate
Sodium (S)-2-(12-ethyl-8-(hydroxymethyl)-2-oxido-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)-2-hydroxybutanoate
Catalogue No.:PA 09 0151007
CAS :
NA
Molecular Formula : C22H20N2Na2O6
Molecular Weight : 454.39
Irinotecan - Impurity A (Hydrochloride Trihydrate Salt)
(S)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate
Catalogue No.:PA 09 0160011
CAS :
158406-44-1
Molecular Formula : C31H41ClN4O9
Molecular Weight : 649.14
(S)-6-(([1,4'-Bipiperidine]-1'-carbonyl)oxy)-4-ethyl-2-(4-ethyl-4-hydroxy-3,8-dioxo-3,4,7,8-tetrahydro-1H-pyrano[3,4-c]pyridin-6-yl)quinoline-3-carboxylic Acid
(S)-6-(([1,4'-Bipiperidine]-1'-carbonyl)oxy)-4-ethyl-2-(4-ethyl-4-hydroxy-3,8-dioxo-3,4,7,8-tetrahydro-1H-pyrano[3,4-c]pyridin-6-yl)quinoline-3-carboxylic Acid
Catalogue No.:PA 09 0151009
CAS :
2252499-29-7
Molecular Formula : C33H38N4O8
Molecular Weight : 618.69
(S)-2-(12-Ethyl-2-hydroxy-8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)-2-hydroxybutanoic Acid
(S)-2-(12-Ethyl-2-hydroxy-8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)-2-hydroxybutanoic Acid
Catalogue No.:PA 09 0151010
CAS :
142677-15-4
Molecular Formula : C22H22N2O6
Molecular Weight : 410.43
