levothyroxine and its Impurities
A synthetic form of thyroid hormone, Thyroxine. Levothyroxine is used in the treatment of thyroid hormone deficiency and certain types of thyroid tumors. It is a levorotatory enantiomer of Thyroxine. Reference standards of Levothyroxine API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
(S)-2-Amino-3-(4-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic Acid
(S)-2-Amino-3-(4-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic Acid
Catalogue No.:PA 12 15610
CAS :
2086274-34-0
Molecular Formula : C21H14I5NO5
Molecular Weight : 994.86
(S)-2-Amino-3-(4-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenoxy)-3,5-diiodophenyl)propanoic Acid
(S)-2-Amino-3-(4-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenoxy)-3,5-diiodophenyl)propanoic Acid
Catalogue No.:PA 12 15630
CAS :
2514763-69-8
Molecular Formula : C21H14I5NO5
Molecular Weight : 994.86
Levothyroxine for Peak Identification (levothyroxine sodium spiked with liothyronine, triiodothyroa (1365021)
Levothyroxine for Peak Identification (levothyroxine sodium spiked with liothyronine, triiodothyroa (1365021)
Catalogue No.:PA USP1365021
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA
2,3,4-Trifluoro-α-[[[(1S)-2-hydroxy-1-methylethyl]amino]methylene]-β-oxo-benzenepropanoic Acid Ethyl Ester
2,3,4-Trifluoro-α-[[[(1S)-2-hydroxy-1-methylethyl]amino]methylene]-β-oxo-benzenepropanoic Acid Ethyl Ester
Catalogue No.:PA 12 15870
CAS :
601490-35-1
Molecular Formula : C15H16F3NO4
Molecular Weight : 331.29
Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoate
Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoate
Catalogue No.:PAI 12 008080
CAS :
NA
Molecular Formula : C21H22I3NO6
Molecular Weight : 765.12
(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic Acid
(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic Acid
Catalogue No.:PAI 12 008090
CAS :
NA
Molecular Formula : C20H20I3NO6
Molecular Weight : 751.09
Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate
Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate
Catalogue No.:PAI 12 008100
CAS :
NA
Molecular Formula : C21H21I4NO6
Molecular Weight : 891.02
Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-(4-((tert-butyldimethylsilyl)oxy)phenoxy)-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate
Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-(4-((tert-butyldimethylsilyl)oxy)phenoxy)-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate
Catalogue No.:PAI 12 008110
CAS :
NA
Molecular Formula : C33H39I4NO7Si
Molecular Weight : 1097.38
Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-(4-hydroxyphenoxy)-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate
Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-(4-hydroxyphenoxy)-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate
Catalogue No.:PAI 12 008120
CAS :
NA
Molecular Formula : C27H25I4NO7
Molecular Weight : 983.11
Ethyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate
Ethyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate
Catalogue No.:PAI 12 008130
CAS :
NA
Molecular Formula : C27H23I6NO7
Molecular Weight : 1234.91
(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic Acid
(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic Acid
Catalogue No.:PAI 12 008140
CAS :
NA
Molecular Formula : C26H21I6NO7
Molecular Weight : 1220.88
(2R,3R,4S,5R,6R)-6-(Acetoxymethyl)-5-(((2S,3R,4S,5S,6R)-3,4,5-triacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2,3,4-triyl Triacetate
(2R,3R,4S,5R,6R)-6-(Acetoxymethyl)-5-(((2S,3R,4S,5S,6R)-3,4,5-triacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2,3,4-triyl Triacetate
Catalogue No.:PAI 12 008150
CAS :
NA
Molecular Formula : C28H38O19
Molecular Weight : 678.59
(2R,3S,4S,5R,6S)-2-(Acetoxymethyl)-6-(((2R,3R,4S,5R,6S)-4,5-diacetoxy-2-(acetoxymethyl)-6-(((S)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-1-methoxy-1-oxopropan-2-yl)amino)tetrahydro-2H-pyran-3-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl Triacetate
(2R,3S,4S,5R,6S)-2-(Acetoxymethyl)-6-(((2R,3R,4S,5R,6S)-4,5-diacetoxy-2-(acetoxymethyl)-6-(((S)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-1-methoxy-1-oxopropan-2-yl)amino)tetrahydro-2H-pyran-3-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl Triacetate
Catalogue No.:PAI 12 008160
CAS :
NA
Molecular Formula : C42H47I4NO2
Molecular Weight : 1409.44
(S)-2-(((2S,3R,4S,5R,6R)-3,4-Diacetoxy-6-(acetoxymethyl)-5-(((2S,3R,4S,5S,6R)-3,4,5-triacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)amino)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic Acid
(S)-2-(((2S,3R,4S,5R,6R)-3,4-Diacetoxy-6-(acetoxymethyl)-5-(((2S,3R,4S,5S,6R)-3,4,5-triacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)amino)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic Acid
Catalogue No.:PAI 12 008170
CAS :
NA
Molecular Formula : C41H45I4NO21
Molecular Weight : 1395.41
Methyl (S)-2-(((2S,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)amino)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate
Methyl (S)-2-(((2S,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)amino)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate
Catalogue No.:PAI 12 008180
CAS :
NA
Molecular Formula : C28H33I4NO14
Molecular Weight : 1115.18
Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-5-iodo-4-(4-methoxyphenoxy)phenyl)propanoate,
Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-5-iodo-4-(4-methoxyphenoxy)phenyl)propanoate,
Catalogue No.:PAI 12 008230
CAS :
NA
Molecular Formula : C22H25ClINO6
Molecular Weight : 561.81
4-(4-((tert-Butyldimethylsilyl)oxy)-3,5-diiodophenoxy)-3,5-diiodobenzyl 4-methylbenzenesulfonate
4-(4-((tert-Butyldimethylsilyl)oxy)-3,5-diiodophenoxy)-3,5-diiodobenzyl 4-methylbenzenesulfonate
Catalogue No.:PAI 12 008246
CAS :
NA
Molecular Formula : C26H28I4O5SSi
Molecular Weight : 988.27