Methotrexate-impurities | Pharmaffiliates

methotrexate and its Impurities

An antimetabolite of the antifolate type, Methotrexate is an chemotherapy drug and used for treating autoimmune diseases like psoriasis, rheumatoid arthritis. It causes life threatening side effects. Reference standards of Methotrexate API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

Displaying 75 results for methotrexate Impurities
PA 13 28000

Methotrexate - API Standards

Methotrexate


  • Catalogue No.:PA 13 28000

  • CAS :

    59-05-2

  • Molecular Formula : C20H22N8O5

  • Molecular Weight : 454.44

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PA 13 28010

Methotrexate - Impurity A (Freebase)

(2,4-Diaminopteridin-6-yl)methanol


  • Catalogue No.:PA 13 28010

  • CAS :

    945-24-4

  • Molecular Formula : C7H8N6O

  • Molecular Weight : 192.18

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PA 13 28020

Methotrexate - Impurity B (Freebase)

Aminopterin


  • Catalogue No.:PA 13 28020

  • CAS :

    54-62-6

  • Molecular Formula : C19H20N8O5

  • Molecular Weight : 440.41

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PA 13 28050

Methotrexate - Impurity E (HCl Salt)

4-amino-N10-methylpteroic acid, APA Hydrochloride


  • Catalogue No.:PA 13 28050

  • CAS :

    70844-48-3

  • Molecular Formula : C30H31ClN14O4

  • Molecular Weight : 687.12

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PA 13 0280011

Methotrexate - Impurity A (Hydrochloride Salt)

2,4-Diamino-6-pteridinemethanol Hydrochloride Salt


  • Catalogue No.:PA 13 0280011

  • CAS :

    73978-41-3

  • Molecular Formula : C7H9ClN6O

  • Molecular Weight : 228.64

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PA 13 0281010

7-Methylpteridine-2,4-diamine

7-Methylpteridine-2,4-diamine


  • Catalogue No.:PA 13 0281010

  • CAS :

    4215-07-0

  • Molecular Formula : C7H8N6

  • Molecular Weight : 176.18

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PA 13 0280021

Methotrexate - Impurity B (Hydrate Salt)

(4-(((2,4-diaminopteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid hydrate


  • Catalogue No.:PA 13 0280021

  • CAS :

    1217459-90-9

  • Molecular Formula : C19H22N8O6

  • Molecular Weight : 458.44

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PA 13 28030

Methotrexate - Impurity C (Freebase)

Methopteridine


  • Catalogue No.:PA 13 28030

  • CAS :

    2410-93-7

  • Molecular Formula : C20H21N7O6

  • Molecular Weight : 455.42

PA 13 28040

Methotrexate - Impurity D

N10-Methyl Pteroic Acid


  • Catalogue No.:PA 13 28040

  • CAS :

    5623-18-7

  • Molecular Formula : C15H14N6O3

  • Molecular Weight : 326.31

PA 13 28060

Methotrexate - Impurity F (Freebase)

(R)-Methotrexate


  • Catalogue No.:PA 13 28060

  • CAS :

    51865-79-3

  • Molecular Formula : C20H22N8O5

  • Molecular Weight : 454.44

PA 13 28080

Methotrexate - Impurity H (Freebase)

(2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]-4-(methoxycarbonyl)butanoic Acid


  • Catalogue No.:PA 13 28080

  • CAS :

    67022-39-3

  • Molecular Formula : C21H24N8O5

  • Molecular Weight : 468.47

PA 13 28090

Methotrexate - Impurity I (Freebase)

(4S)-4-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]-4-(methoxycarbonyl)butanoic Acid


  • Catalogue No.:PA 13 28090

  • CAS :

    66147-29-3

  • Molecular Formula : C21H24N8O5

  • Molecular Weight : 468.47

PA 13 28100

Methotrexate - Impurity J

Methotrexate Dimethyl Ester


  • Catalogue No.:PA 13 28100

  • CAS :

    34378-65-9

  • Molecular Formula : C22H26N8O5

  • Molecular Weight : 482.49

PA 13 28510

Methotrexate Triglutamate Trifluoroacetate

Methotrexate Triglutamate Trifluoroacetate


  • Catalogue No.:PA 13 28510

  • CAS :

    NA

  • Molecular Formula : C30H36N10O11 xC2HF3O2

  • Molecular Weight : 712.67

PA 13 28520

Methotrexate Tetraglutamate Trifluoroacetate

Methotrexate Tetraglutamate Trifluoroacetate


  • Catalogue No.:PA 13 28520

  • CAS :

    NA

  • Molecular Formula : C35H43N11O14 xC2HF3O2

  • Molecular Weight : 841.78

PA 13 28530

Methotrexate Pentaglutamate Trifluoroacetate

Methotrexate Pentaglutamate Trifluoroacetate


  • Catalogue No.:PA 13 28530

  • CAS :

    NA

  • Molecular Formula : C40H50N12O17 xC2HF3O2

  • Molecular Weight : 970.9

PA STI 061720

Methopterine-d3

Methopterine-d3


  • Catalogue No.:PA STI 061720

  • CAS :

    NA

  • Molecular Formula : C20H18D3N7O6

  • Molecular Weight : 458.44

PA STI 049680

7-Hydroxy Methotrexate-d3

7-Hydroxy Methotrexate-d3


  • Catalogue No.:PA STI 049680

  • CAS :

    432545-62-5

  • Molecular Formula : C20H19D3N8O6

  • Molecular Weight : 473.46

PA STI 059080

Methotrexate-d3

Methotrexate-d3


  • Catalogue No.:PA STI 059080

  • CAS :

    432545-63-6

  • Molecular Formula : C20H19D3N8O5

  • Molecular Weight : 457.46

PA STI 059090

DL-Methotrexate-d3 Dipotassium Salt

DL-Methotrexate-d3 Dipotassium Salt


  • Catalogue No.:PA STI 059090

  • CAS :

    NA

  • Molecular Formula : C20H17D3K2N8O5

  • Molecular Weight : 533.64

PA 13 28540

Methotrexate Dimethylamide

Methotrexate Dimethylamide


  • Catalogue No.:PA 13 28540

  • CAS :

    71074-44-7

  • Molecular Formula : C22H27N9O4

  • Molecular Weight : 481.52

PA 13 28550

(+/-)Amethopterin

(+/-)Amethopterin


  • Catalogue No.:PA 13 28550

  • CAS :

    60388-53-6

  • Molecular Formula : C20H22N8O5

  • Molecular Weight : 454.44

PA 13 28560

N-(4-Aminobenzoyl)-D-glutamic acid

N-(4-Aminobenzoyl)-D-glutamic acid


  • Catalogue No.:PA 13 28560

  • CAS :

    5959-18-2

  • Molecular Formula : C12H14N2O5

  • Molecular Weight : 266.25

Methotrexate (ICRS0345)


  • Catalogue No.:PA ICRS0345

  • CAS :

    NA

  • Molecular Formula :

  • Molecular Weight : NA

Methotrexate (IPRS/231/12)-from IPC


  • Catalogue No.:PA IPIPRS 231 12

  • CAS :

    NA

  • Molecular Formula :

  • Molecular Weight : NA

Methotrexate (JP 0148)

Methotrexate (JP 0148)


  • Catalogue No.:PA JP0148

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

Methotrexate (M1000000)

Methotrexate (M1000000)


  • Catalogue No.:PA EPM1000000

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

Methotrexate impurity D (M1000008)

Methotrexate impurity D (M1000008)


  • Catalogue No.:PA EPM1000008

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

Methotrexate for peak identification (Y0000602)

Methotrexate for peak identification (Y0000602)


  • Catalogue No.:PA EPY0000602

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

Methotrexate impurity C (Y0000663)

Methotrexate impurity C (Y0000663)


  • Catalogue No.:PA EPY0000663

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

Methotrexate impurity E (Y0000664)

Methotrexate impurity E (Y0000664)


  • Catalogue No.:PA EPY0000664

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

Methotrexate for system suitability (Y0001668)

Methotrexate for system suitability (Y0001668)


  • Catalogue No.:PA EPY0001668

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

R-Methotrexate ((R)-2-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzamido)pentanedioic ac (1413988)

R-Methotrexate ((R)-2-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzamido)pentanedioic ac (1413988)


  • Catalogue No.:PA USP1413988

  • CAS :

    59-05-2

  • Molecular Formula : NA

  • Molecular Weight : NA

Methotrexate System Suitability Mixture (1413999)

Methotrexate System Suitability Mixture (1413999)


  • Catalogue No.:PA USP1413999

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

Methotrexate (1414003)

Methotrexate (1414003)


  • Catalogue No.:PA USP1414003

  • CAS :

    59-05-2

  • Molecular Formula : NA

  • Molecular Weight : NA

Methotrexate Related Compound B ((S)-2-{4-[(2,4-diaminopteridin-6-yl)methylamino]benzamido}pentaned (1414025)

Methotrexate Related Compound B ((S)-2-{4-[(2,4-diaminopteridin-6-yl)methylamino]benzamido}pentaned (1414025)


  • Catalogue No.:PA USP1414025

  • CAS :

    54-62-6

  • Molecular Formula : NA

  • Molecular Weight : NA

Methotrexate Related Compound C ((S)-2-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](methyl) (1414036)

Methotrexate Related Compound C ((S)-2-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](methyl) (1414036)


  • Catalogue No.:PA USP1414036

  • CAS :

    2410-93-7

  • Molecular Formula : NA

  • Molecular Weight : NA

Methotrexate Related Compound E (4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoic acid, h (1414058)

Methotrexate Related Compound E (4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoic acid, h (1414058)


  • Catalogue No.:PA USP1414058

  • CAS :

    70844-48-3

  • Molecular Formula : NA

  • Molecular Weight : NA

PA 13 28570

4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic Acid Methyl Ester

4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic Acid Methyl Ester


  • Catalogue No.:PA 13 28570

  • CAS :

    34794-87-1

  • Molecular Formula : C15H14N6O3

  • Molecular Weight : 326.31

PA 13 28120

Methotrexate - Impurity L

(2S)-2-[[4-(Methylamino)benzoyl]amino]pentanedioic Acid


  • Catalogue No.:PA 13 28120

  • CAS :

    52980-68-4

  • Molecular Formula : C13H16N2O5

  • Molecular Weight : 280.28

PA 13 28070

Methotrexate - Impurity G

(2S)-2-[[4-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]methylamino]benzoyl]amino]pentanedioic Acid


  • Catalogue No.:PA 13 28070

  • CAS :

    2519848-42-9

  • Molecular Formula : C28H29N9O6

  • Molecular Weight : 587.60

PA 13 28110

Methotrexate - Impurity K

(2S)-2-[(4-Aminobenzoyl)amino]pentanedioic Acid


  • Catalogue No.:PA 13 28110

  • CAS :

    4271-30-1

  • Molecular Formula : C12H14N2O5

  • Molecular Weight : 266.25

PA 13 0281000

10-Deazaaminopterin

10-Deazaaminopterin


  • Catalogue No.:PA 13 0281000

  • CAS :

    52454-37-2

  • Molecular Formula : C20H21N7O5

  • Molecular Weight : 439.43

PA 13 0281001

7-Cyanomethotrexate Dimethyl Ester

7-Cyanomethotrexate Dimethyl Ester


  • Catalogue No.:PA 13 0281001

  • CAS :

    112163-39-0

  • Molecular Formula : C23H25N9O5

  • Molecular Weight : 507.51

PA 13 0281002

Methotrexate-d3 Dimethyl Ester

Methotrexate-d3 Dimethyl Ester


  • Catalogue No.:PA 13 0281002

  • CAS :

    432545-60-3

  • Molecular Formula : C22H23D3N8O5

  • Molecular Weight : 485.52

PA 13 0281003

7-Hydroxy Methotrexate

7-Hydroxy Methotrexate


  • Catalogue No.:PA 13 0281003

  • CAS :

    5939-37-7

  • Molecular Formula : C20H22N8O6

  • Molecular Weight : 470.45

PA 13 0281004

(2,4-Diaminopteridin-7-yl)methanol

(2,4-Diaminopteridin-7-yl)methanol


  • Catalogue No.:PA 13 0281004

  • CAS :

    881-33-4

  • Molecular Formula : C7H8N6O

  • Molecular Weight : 192.18

PA 13 0281005

2,4-Diaminopteridine

2,4-Diaminopteridine


  • Catalogue No.:PA 13 0281005

  • CAS :

    1127-93-1

  • Molecular Formula : C6H6N6

  • Molecular Weight : 162.16

PA 13 0281006

6-Methylpteridine-2,4-diamine

6-Methylpteridine-2,4-diamine


  • Catalogue No.:PA 13 0281006

  • CAS :

    708-74-7

  • Molecular Formula : C7H8N6

  • Molecular Weight : 176.18

PA 13 0281007

(4-Chlorobenzoyl)-L-glutamic Acid

(4-Chlorobenzoyl)-L-glutamic Acid


  • Catalogue No.:PA 13 0281007

  • CAS :

    57444-70-9

  • Molecular Formula : C12H12ClNO5

  • Molecular Weight : 285.68

PA 13 0281008

Methotrexate System Suitability Mixture

Methotrexate System Suitability Mixture


  • Catalogue No.:PA 13 0281008

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

PA 13 0281009

Aminopterin-α-hyrazide

Aminopterin-α-hyrazide


  • Catalogue No.:PA 13 0281009

  • CAS :

    118359-33-4

  • Molecular Formula : C19H22N10O4

  • Molecular Weight : 454.45

PA 13 0280051

Methotrexate - Impurity E (Freebase)

4-Amino-N10-methylpteroic acid, APA


  • Catalogue No.:PA 13 0280051

  • CAS :

    19741-14-1

  • Molecular Formula : C15H15N7O2

  • Molecular Weight : 325.33

PA 13 0281011

Diethyl (4-(methylamino)benzoyl)-L-glutamate

Diethyl (4-(methylamino)benzoyl)-L-glutamate


  • Catalogue No.:PA 13 0281011

  • CAS :

    2378-95-2

  • Molecular Formula : C17H24N2O5

  • Molecular Weight : 336.39

PA 13 0281012

Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)-N-nitrosobenzamido)-2-methylpentanedioate

Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)-N-nitrosobenzamido)-2-methylpentanedioate


  • Catalogue No.:PA 13 0281012

  • CAS :

    NA

  • Molecular Formula : C21H21N9Na2O6

  • Molecular Weight : 541.44

PA 13 0281013

(4-(((2,4-Diaminopteridin-6-yl)methyl)(nitroso)amino)benzoyl)-L-glutamic Acid

(4-(((2,4-Diaminopteridin-6-yl)methyl)(nitroso)amino)benzoyl)-L-glutamic Acid


  • Catalogue No.:PA 13 0281013

  • CAS :

    NA

  • Molecular Formula : C19H19N9O6

  • Molecular Weight : 469.42

PA 13 0281014

N-(4-(Methylamino)benzoyl)-N-nitroso-L-glutamic Acid

N-(4-(Methylamino)benzoyl)-N-nitroso-L-glutamic Acid


  • Catalogue No.:PA 13 0281014

  • CAS :

    NA

  • Molecular Formula : C13H15N3O6

  • Molecular Weight : 309.28

PA 13 0281015

(4-(Methyl(nitroso)amino)benzoyl)-L-glutamic Acid

(4-(Methyl(nitroso)amino)benzoyl)-L-glutamic Acid


  • Catalogue No.:PA 13 0281015

  • CAS :

    NA

  • Molecular Formula : C13H15N3O6

  • Molecular Weight : 309.28

PA 13 0281016

N-(4-(Methyl(nitroso)amino)benzoyl)-N-nitroso-L-glutamic Acid

N-(4-(Methyl(nitroso)amino)benzoyl)-N-nitroso-L-glutamic Acid


  • Catalogue No.:PA 13 0281016

  • CAS :

    NA

  • Molecular Formula : C13H14N4O7

  • Molecular Weight : 338.28

PA 13 0281017

(4-(Methylamino)benzoyl)-D-glutamic Acid

(4-(Methylamino)benzoyl)-D-glutamic Acid


  • Catalogue No.:PA 13 0281017

  • CAS :

    52030-86-1

  • Molecular Formula : C13H16N2O5

  • Molecular Weight : 280.28

PA 13 0281018

(2,4-Diaminopteridine-6,7-diyl)dimethanol

(2,4-Diaminopteridine-6,7-diyl)dimethanol


  • Catalogue No.:PA 13 0281018

  • CAS :

    NA

  • Molecular Formula : C8H10N6O2

  • Molecular Weight : 222.21

PA 13 0281019

Diethyl (4-(methylamino)benzoyl)-D-glutamate

Diethyl (4-(methylamino)benzoyl)-D-glutamate


  • Catalogue No.:PA 13 0281019

  • CAS :

    51865-66-8

  • Molecular Formula : C17H24N2O5

  • Molecular Weight : 336.39

PA 13 0281020

Diethyl (4-(dimethylamino)benzoyl)-L-glutamate

Diethyl (4-(dimethylamino)benzoyl)-L-glutamate


  • Catalogue No.:PA 13 0281020

  • CAS :

    909874-43-7

  • Molecular Formula : C18H26N2O5

  • Molecular Weight : 350.42

PA 13 0281021

Diethyl (4-chlorobenzoyl)-L-glutamate

Diethyl (4-chlorobenzoyl)-L-glutamate


  • Catalogue No.:PA 13 0281021

  • CAS :

    NA

  • Molecular Formula : C16H20ClNO5

  • Molecular Weight : 341.79

PA 13 0281022

Diethyl (4-hydroxybenzoyl)-L-glutamate

Diethyl (4-hydroxybenzoyl)-L-glutamate


  • Catalogue No.:PA 13 0281022

  • CAS :

    57963-63-0

  • Molecular Formula : C16H21NO6

  • Molecular Weight : 323.35

PA 13 0280121

Methotrexate - Impurity L (Zinc Salt)

(2S)-2-[[4-(Methylamino)benzoyl]amino]pentanedioic Acid Zinc Salt


  • Catalogue No.:PA 13 0280121

  • CAS :

    66104-81-2

  • Molecular Formula : C13H14N2O5Zn

  • Molecular Weight : 343.64

PA 13 0281024

Methotrexate Diethyl Ester

Methotrexate Diethyl Ester


  • Catalogue No.:PA 13 0281024

  • CAS :

    43170-88-3

  • Molecular Formula : C24H30N8O5

  • Molecular Weight : 510.56

PA 13 0281025

(S)-5-Ethoxy-2-(4-(methylamino)benzamido)-5-oxopentanoic Acid

(S)-5-Ethoxy-2-(4-(methylamino)benzamido)-5-oxopentanoic Acid


  • Catalogue No.:PA 13 0281025

  • CAS :

    NA

  • Molecular Formula : C15H20N2O5

  • Molecular Weight : 308.33

PA 13 0281026

(S)-5-Ethoxy-4-(4-(methylamino)benzamido)-5-oxopentanoic Acid

(S)-5-Ethoxy-4-(4-(methylamino)benzamido)-5-oxopentanoic Acid


  • Catalogue No.:PA 13 0281026

  • CAS :

    NA

  • Molecular Formula : C15H20N2O5

  • Molecular Weight : 308.33

PA 13 0281027

(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-ethoxy-5-oxopentanoic Acid

(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-ethoxy-5-oxopentanoic Acid


  • Catalogue No.:PA 13 0281027

  • CAS :

    65148-64-3

  • Molecular Formula : C22H26N8O5

  • Molecular Weight : 482.5

PA 13 0281028

(S)-4-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-ethoxy-5-oxopentanoic Acid

(S)-4-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-ethoxy-5-oxopentanoic Acid


  • Catalogue No.:PA 13 0281028

  • CAS :

    65148-63-2

  • Molecular Formula : C22H26N8O5

  • Molecular Weight : 482.5

Methotrexate (IPRS/83/18)

Methotrexate (IPRS/83/18)


  • Catalogue No.:PA IPRS 83 18

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

PA 13 0281029

N-(4,6-Diaminopyrimidin-2-yl)nitrous Amide

N-(4,6-Diaminopyrimidin-2-yl)nitrous Amide


  • Catalogue No.:PA 13 0281029

  • CAS :

    NA

  • Molecular Formula : C4H6N6O

  • Molecular Weight : 154.13

PA 13 0281030

Diethyl (3-(methylamino)benzoyl)-L-glutamate

Diethyl (3-(methylamino)benzoyl)-L-glutamate


  • Catalogue No.:PA 13 0281030

  • CAS :

    2820151-35-5

  • Molecular Formula : C17H24N2O5

  • Molecular Weight : 336.39

PA 13 0281031

Diethyl (2-(methylamino)benzoyl)-L-glutamate

Diethyl (2-(methylamino)benzoyl)-L-glutamate


  • Catalogue No.:PA 13 0281031

  • CAS :

    1029980-84-4

  • Molecular Formula : C17H24N2O5

  • Molecular Weight : 336.39