nintedanib and its Impurities
A Nintedanib is used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer. It is a small molecule kinase inhibitor. Reference standards of Nintedanib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(Z)-3-(((4-(N-Methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylic Acid
(Z)-3-(((4-(N-Methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylic Acid
Catalogue No.:PA 14 54520
CAS :
894783-71-2
Molecular Formula : C30H31N5O4
Molecular Weight : 525.6


(Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide
(Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide
Catalogue No.:PA 14 54530
CAS :
3029899-97-3
Molecular Formula : C31H33N5O6
Molecular Weight : 571.62


(Z)-Methyl 3-((methyl(4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
(Z)-Methyl 3-((methyl(4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 54540
CAS :
NA
Molecular Formula : C32H35N5O4
Molecular Weight : 553.65


(Z)-Methyl 1-acetyl-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
(Z)-Methyl 1-acetyl-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 54560
CAS :
2380229-45-6
Molecular Formula : C33H35N5O5
Molecular Weight : 581.66


(Z)-Methyl 3-(((4-(N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
(Z)-Methyl 3-(((4-(N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 54570
CAS :
1139458-48-2
Molecular Formula : C26H23N3O4
Molecular Weight : 441.48


(3Z,3'Z)-Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))bis(2-oxoindoline-6-carboxylate)
(3Z,3'Z)-Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))bis(2-oxoindoline-6-carboxylate)
Catalogue No.:PA 14 54580
CAS :
2410284-90-9
Molecular Formula : C56H52N8O8
Molecular Weight : 965.06


Methyl (3Z)-3-[({4-[2-(4-ethylpiperazin-1-yl)-N-methylacetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
Methyl (3Z)-3-[({4-[2-(4-ethylpiperazin-1-yl)-N-methylacetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
Catalogue No.:PA 14 54590
CAS :
NA
Molecular Formula : C32H35N5O4
Molecular Weight : 553.65


(Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1-oxide
(Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1-oxide
Catalogue No.:PA 14 54600
CAS :
3029792-00-2
Molecular Formula : C31H33N5O5
Molecular Weight : 555.62


Ethyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
Ethyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
Catalogue No.:PA 14 54610
CAS :
1139455-52-9
Molecular Formula : C32H35N5O4
Molecular Weight : 553.65


(3E)-1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic Acid Methyl Ester
(3E)-1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic Acid Methyl Ester
Catalogue No.:PA 14 54660
CAS :
1168152-06-4
Molecular Formula : C21H19NO5
Molecular Weight : 365.38


Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-7-carboxylate
Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-7-carboxylate
Catalogue No.:PA 14 0541004
CAS :
NA
Molecular Formula : C31H33N5O4
Molecular Weight : 539.64


Methyl (E)-1-acetyl-3-(((4-(2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Methyl (E)-1-acetyl-3-(((4-(2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541006
CAS :
NA
Molecular Formula : C32H33N5O5
Molecular Weight : 567.65


Methyl (E)-3-(((4-(N-methyl-2-(piperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Methyl (E)-3-(((4-(N-methyl-2-(piperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541007
CAS :
NA
Molecular Formula : C30H31N5O4
Molecular Weight : 525.61


Ethyl (E)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Ethyl (E)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541010
CAS :
NA
Molecular Formula : C32H35N5O4
Molecular Weight : 553.66


N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-(((2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)acetamide
N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-(((2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)acetamide
Catalogue No.:PA 14 0541014
CAS :
1610881-60-1
Molecular Formula : C29H31N5O2
Molecular Weight : 481.6


Methyl (Z)-1-(2-methoxy-2-oxoethyl)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Methyl (Z)-1-(2-methoxy-2-oxoethyl)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541016
CAS :
NA
Molecular Formula : C34H37N5O6
Molecular Weight : 611.7


Isopropyl (Z)-1-(2-methoxy-2-oxoethyl)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Isopropyl (Z)-1-(2-methoxy-2-oxoethyl)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541017
CAS :
NA
Molecular Formula : C36H41N5O6
Molecular Weight : 639.75


(E)-3-(((4-(2-(4-Methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylic acid
(E)-3-(((4-(2-(4-Methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylic acid
Catalogue No.:PA 14 0541020
CAS :
NA
Molecular Formula : C29H29N5O4
Molecular Weight : 511.58


(2S,3S,4S,5R,6R)-4,5,6-Trihydroxy-2-((((Z)-6-(methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)(4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)tetrahydro-2H-pyran-3-carboxylic acid
(2S,3S,4S,5R,6R)-4,5,6-Trihydroxy-2-((((Z)-6-(methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)(4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)tetrahydro-2H-pyran-3-carboxylic acid
Catalogue No.:PA 14 0541021
CAS :
NA
Molecular Formula : C37H41N5O10
Molecular Weight : 715.76


(Z)-4-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-1-methylpiperazine 1-oxide
(Z)-4-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-1-methylpiperazine 1-oxide
Catalogue No.:PA 14 0541024
CAS :
3029792-02-4
Molecular Formula : C31H33N5O5
Molecular Weight : 555.64


Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541030
CAS :
1160294-26-7
Molecular Formula : C31H33N5O4
Molecular Weight : 539.64


Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)(nitroso)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)(nitroso)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541034
CAS :
NA
Molecular Formula : C31H32N6O5
Molecular Weight : 568.63


Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxo-1-propionylindoline-6-carboxylate
Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxo-1-propionylindoline-6-carboxylate
Catalogue No.:PA 14 0541035
CAS :
2097505-01-4
Molecular Formula : C34H37N5O5
Molecular Weight : 595.7


Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-1-nitroso-2-oxoindoline-6-carboxylate
Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-1-nitroso-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541038
CAS :
NA
Molecular Formula : C31H32N6O5
Molecular Weight : 568.63


Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))bis(1-acetyl-2-oxoindoline-6-carboxylate)
Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))bis(1-acetyl-2-oxoindoline-6-carboxylate)
Catalogue No.:PA 14 0541044
CAS :
2410649-55-5
Molecular Formula : C60H56N8O10
Molecular Weight : 1049.15


1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide
1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide
Catalogue No.:PA 14 0541045
CAS :
2734676-68-5
Molecular Formula : C31H33N5O6
Molecular Weight : 571.63


Methyl (Z)-3-(((4-(methylamino)phenyl)(nitroso)amino)(phenyl)methylene)-2-oxoindoline-5-carboxylate
Methyl (Z)-3-(((4-(methylamino)phenyl)(nitroso)amino)(phenyl)methylene)-2-oxoindoline-5-carboxylate
Catalogue No.:PA 14 0541058
CAS :
NA
Molecular Formula : C24H20N4O4
Molecular Weight : 428.45


Methyl (Z)-3-((4-(2-((4-((((Z)-6-(methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)piperazin-1-yl)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Methyl (Z)-3-((4-(2-((4-((((Z)-6-(methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)piperazin-1-yl)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541060
CAS :
NA
Molecular Formula : C47H42N6O7
Molecular Weight : 802.89


Methyl (Z)-3-(1-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)ethylidene)-2-oxoindoline-6-carboxylate
Methyl (Z)-3-(1-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)ethylidene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541063
CAS :
NA
Molecular Formula : C26H31N5O4
Molecular Weight : 477.57


Methyl (Z)-3-(((4-(N-methyl-2-(piperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Methyl (Z)-3-(((4-(N-methyl-2-(piperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541064
CAS :
334951-61-0
Molecular Formula : C30H31N5O4
Molecular Weight : 525.61


Methyl (E)-3-(((4-(2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-7-carboxylate
Methyl (E)-3-(((4-(2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-7-carboxylate
Catalogue No.:PA 14 0541066
CAS :
NA
Molecular Formula : C30H31N5O4
Molecular Weight : 525.61