methotrexate

Metabolites - An antimetabolite of the antifolate type, Methotrexate is an chemotherapy drug and used for treating autoimmune diseases like psoriasis, rheumatoid arthritis. It causes life threatening side effects. Reference standards of Methotrexate API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => 7-Hydroxy Methotrexate-d3
    [catalogue_number] => PA STI 049680
    [category_ids] => ,98,76,78,70,82,
    [chemical_name] => 
    [weight] => 473.46
    [form] => C20H19D3N8O6
    [cas] => 432545-62-5
    [pslug] => 432545-62-5-7-hydroxy-methotrexate-d3-pasti049680
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PA STI 049680
PA STI 049680

7-Hydroxy Methotrexate-d3


  • Catalogue No.:PA STI 049680

  • CAS :

    432545-62-5

  • Molecular Formula : C20H19D3N8O6

  • Molecular Weight : 473.46

stdClass Object
(
    [pname] => Methotrexate - Impurity K
    [catalogue_number] => PA 13 28110
    [category_ids] => ,75,76,97,
    [chemical_name] => 
    [weight] => 266.25
    [form] => C12H14N2O5
    [cas] => 4271-30-1
    [pslug] => 4271-30-1-methotrexate-impurity-k-pa1328110
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PA 13 28110
PA 13 28110

Methotrexate - Impurity K


  • Catalogue No.:PA 13 28110

  • CAS :

    4271-30-1

  • Molecular Formula : C12H14N2O5

  • Molecular Weight : 266.25

stdClass Object
(
    [pname] => 10-Deazaaminopterin
    [catalogue_number] => PA 13 0281000
    [category_ids] => ,75,76,123,81,70,78,82,
    [chemical_name] => 
    [weight] => 439.43
    [form] => C20H21N7O5
    [cas] => 52454-37-2
    [pslug] => 52454-37-2-10-deazaaminopterin-pa130281000
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PA 13 0281000
PA 13 0281000

10-Deazaaminopterin


  • Catalogue No.:PA 13 0281000

  • CAS :

    52454-37-2

  • Molecular Formula : C20H21N7O5

  • Molecular Weight : 439.43

stdClass Object
(
    [pname] => Methotrexate - Impurity A (Hydrochloride Salt)
    [catalogue_number] => PA 13 0280011
    [category_ids] => ,78,75,76,82,
    [chemical_name] => 
    [weight] => 228.64
    [form] => C7H9ClN6O
    [cas] => 73978-41-3
    [pslug] => 73978-41-3-2-4-diamino-6-pteridinemethanol-hydrochloride-salt-pa130280011
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PA 13 0280011
PA 13 0280011

Methotrexate - Impurity A (Hydrochloride Salt)


  • Catalogue No.:PA 13 0280011

  • CAS :

    73978-41-3

  • Molecular Formula : C7H9ClN6O

  • Molecular Weight : 228.64

stdClass Object
(
    [pname] => 7-Cyanomethotrexate Dimethyl Ester
    [catalogue_number] => PA 13 0281001
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 507.51
    [form] => C23H25N9O5
    [cas] => 112163-39-0
    [pslug] => 112163-39-0-7-cyanomethotrexate-dimethyl-ester-pa130281001
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PA 13 0281001
PA 13 0281001

7-Cyanomethotrexate Dimethyl Ester


  • Catalogue No.:PA 13 0281001

  • CAS :

    112163-39-0

  • Molecular Formula : C23H25N9O5

  • Molecular Weight : 507.51

stdClass Object
(
    [pname] => Methotrexate-d3 Dimethyl Ester
    [catalogue_number] => PA 13 0281002
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 485.52
    [form] => C22H23D3N8O5
    [cas] => 432545-60-3
    [pslug] => 432545-60-3-methotrexate-d3-dimethyl-ester-pa130281002
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PA 13 0281002
PA 13 0281002

Methotrexate-d3 Dimethyl Ester


  • Catalogue No.:PA 13 0281002

  • CAS :

    432545-60-3

  • Molecular Formula : C22H23D3N8O5

  • Molecular Weight : 485.52

stdClass Object
(
    [pname] => 7-Hydroxy Methotrexate
    [catalogue_number] => PA 13 0281003
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 470.45
    [form] => C20H22N8O6
    [cas] => 5939-37-7
    [pslug] => 5939-37-7-7-hydroxy-methotrexate-pa130281003
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PA 13 0281003
PA 13 0281003

7-Hydroxy Methotrexate


  • Catalogue No.:PA 13 0281003

  • CAS :

    5939-37-7

  • Molecular Formula : C20H22N8O6

  • Molecular Weight : 470.45

stdClass Object
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    [pname] => (2,4-Diaminopteridin-7-yl)methanol
    [catalogue_number] => PA 13 0281004
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 192.18
    [form] => C7H8N6O
    [cas] => 881-33-4
    [pslug] => 881-33-4-2-4-diaminopteridin-7-yl-methanol-pa130281004
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PA 13 0281004
PA 13 0281004

(2,4-Diaminopteridin-7-yl)methanol


  • Catalogue No.:PA 13 0281004

  • CAS :

    881-33-4

  • Molecular Formula : C7H8N6O

  • Molecular Weight : 192.18

stdClass Object
(
    [pname] => 2,4-Diaminopteridine
    [catalogue_number] => PA 13 0281005
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 162.16
    [form] => C6H6N6
    [cas] => 1127-93-1
    [pslug] => 1127-93-1-2-4-diaminopteridine-pa130281005
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PA 13 0281005
PA 13 0281005

2,4-Diaminopteridine


  • Catalogue No.:PA 13 0281005

  • CAS :

    1127-93-1

  • Molecular Formula : C6H6N6

  • Molecular Weight : 162.16

stdClass Object
(
    [pname] => 6-Methylpteridine-2,4-diamine
    [catalogue_number] => PA 13 0281006
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 176.18
    [form] => C7H8N6
    [cas] => 708-74-7
    [pslug] => 708-74-7-6-methylpteridine-2-4-diamine-pa130281006
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PA 13 0281006
PA 13 0281006

6-Methylpteridine-2,4-diamine


  • Catalogue No.:PA 13 0281006

  • CAS :

    708-74-7

  • Molecular Formula : C7H8N6

  • Molecular Weight : 176.18

stdClass Object
(
    [pname] => (4-Chlorobenzoyl)-L-glutamic Acid
    [catalogue_number] => PA 13 0281007
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 285.68
    [form] => C12H12ClNO5
    [cas] => 57444-70-9
    [pslug] => 57444-70-9-4-chlorobenzoyl-l-glutamic-acid-pa130281007
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PA 13 0281007
PA 13 0281007

(4-Chlorobenzoyl)-L-glutamic Acid


  • Catalogue No.:PA 13 0281007

  • CAS :

    57444-70-9

  • Molecular Formula : C12H12ClNO5

  • Molecular Weight : 285.68

stdClass Object
(
    [pname] => Methotrexate System Suitability Mixture
    [catalogue_number] => PA 13 0281008
    [category_ids] => ,80,71,76,75,93,78,70,82,
    [chemical_name] => 
    [weight] => NA
    [form] => NA
    [cas] => NA
    [pslug] => methotrexate-system-suitability-mixture-pa130281008
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PA 13 0281008
PA 13 0281008

Methotrexate System Suitability Mixture


  • Catalogue No.:PA 13 0281008

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

stdClass Object
(
    [pname] => Aminopterin-α-hyrazide
    [catalogue_number] => PA 13 0281009
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 454.45
    [form] => C19H22N10O4
    [cas] => 118359-33-4
    [pslug] => 118359-33-4-aminopterin-alpha-hyrazide-pa130281009
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PA 13 0281009
PA 13 0281009

Aminopterin-α-hyrazide


  • Catalogue No.:PA 13 0281009

  • CAS :

    118359-33-4

  • Molecular Formula : C19H22N10O4

  • Molecular Weight : 454.45

stdClass Object
(
    [pname] => 7-Methylpteridine-2,4-diamine
    [catalogue_number] => PA 13 0281010
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 176.18
    [form] => C7H8N6
    [cas] => 4215-07-0
    [pslug] => 4215-07-0-7-methylpteridine-2-4-diamine-pa130281010
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PA 13 0281010
PA 13 0281010

7-Methylpteridine-2,4-diamine


  • Catalogue No.:PA 13 0281010

  • CAS :

    4215-07-0

  • Molecular Formula : C7H8N6

  • Molecular Weight : 176.18

stdClass Object
(
    [pname] => Methotrexate - Impurity E (Freebase)
    [catalogue_number] => PA 13 0280051
    [category_ids] => ,82,78,76,75,70,
    [chemical_name] => 
    [weight] => 325.33
    [form] => C15H15N7O2
    [cas] => 19741-14-1
    [pslug] => 19741-14-1-methotrexate-impurity-e-freebase-pa130280051
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PA 13 0280051
PA 13 0280051

Methotrexate - Impurity E (Freebase)


  • Catalogue No.:PA 13 0280051

  • CAS :

    19741-14-1

  • Molecular Formula : C15H15N7O2

  • Molecular Weight : 325.33

stdClass Object
(
    [pname] => Diethyl (4-(methylamino)benzoyl)-L-glutamate
    [catalogue_number] => PA 13 0281011
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 336.39
    [form] => C17H24N2O5
    [cas] => 2378-95-2
    [pslug] => 2378-95-2-diethyl-4-methylamino-benzoyl-l-glutamate-pa130281011
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PA 13 0281011
PA 13 0281011

Diethyl (4-(methylamino)benzoyl)-L-glutamate


  • Catalogue No.:PA 13 0281011

  • CAS :

    2378-95-2

  • Molecular Formula : C17H24N2O5

  • Molecular Weight : 336.39

stdClass Object
(
    [pname] => Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)-N-nitrosobenzamido)-2-methylpentanedioate
    [catalogue_number] => PA 13 0281012
    [category_ids] => ,70,75,76,78,82,162,
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    [weight] => 541.44
    [form] => C21H21N9Na2O6
    [cas] => NA
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PA 13 0281012
PA 13 0281012

Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)-N-nitrosobenzamido)-2-methylpentanedioate


  • Catalogue No.:PA 13 0281012

  • CAS :

    NA

  • Molecular Formula : C21H21N9Na2O6

  • Molecular Weight : 541.44

stdClass Object
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    [pname] => (4-(((2,4-Diaminopteridin-6-yl)methyl)(nitroso)amino)benzoyl)-L-glutamic Acid
    [catalogue_number] => PA 13 0281013
    [category_ids] => ,162,82,78,76,75,70,
    [chemical_name] => 
    [weight] => 469.42
    [form] => C19H19N9O6
    [cas] => NA
    [pslug] => 4-2-4-diaminopteridin-6-yl-methyl-nitroso-amino-benzoyl-l-glutamic-acid-pa130281013
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PA 13 0281013
PA 13 0281013

(4-(((2,4-Diaminopteridin-6-yl)methyl)(nitroso)amino)benzoyl)-L-glutamic Acid


  • Catalogue No.:PA 13 0281013

  • CAS :

    NA

  • Molecular Formula : C19H19N9O6

  • Molecular Weight : 469.42

stdClass Object
(
    [pname] => N-(4-(Methylamino)benzoyl)-N-nitroso-L-glutamic Acid
    [catalogue_number] => PA 13 0281014
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 309.28
    [form] => C13H15N3O6
    [cas] => NA
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PA 13 0281014
PA 13 0281014

N-(4-(Methylamino)benzoyl)-N-nitroso-L-glutamic Acid


  • Catalogue No.:PA 13 0281014

  • CAS :

    NA

  • Molecular Formula : C13H15N3O6

  • Molecular Weight : 309.28

stdClass Object
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    [pname] => (4-(Methyl(nitroso)amino)benzoyl)-L-glutamic Acid
    [catalogue_number] => PA 13 0281015
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 309.28
    [form] => C13H15N3O6
    [cas] => NA
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PA 13 0281015
PA 13 0281015

(4-(Methyl(nitroso)amino)benzoyl)-L-glutamic Acid


  • Catalogue No.:PA 13 0281015

  • CAS :

    NA

  • Molecular Formula : C13H15N3O6

  • Molecular Weight : 309.28

stdClass Object
(
    [pname] => N-(4-(Methyl(nitroso)amino)benzoyl)-N-nitroso-L-glutamic Acid
    [catalogue_number] => PA 13 0281016
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 338.28
    [form] => C13H14N4O7
    [cas] => NA
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PA 13 0281016
PA 13 0281016

N-(4-(Methyl(nitroso)amino)benzoyl)-N-nitroso-L-glutamic Acid


  • Catalogue No.:PA 13 0281016

  • CAS :

    NA

  • Molecular Formula : C13H14N4O7

  • Molecular Weight : 338.28

stdClass Object
(
    [pname] => Methotrexate - Impurity B (Hydrate Salt)
    [catalogue_number] => PA 13 0280021
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 458.44
    [form] => C19H22N8O6
    [cas] => 1217459-90-9
    [pslug] => 1217459-90-9-methotrexate-impurity-b-hydrate-salt-pa130280021
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PA 13 0280021
PA 13 0280021

Methotrexate - Impurity B (Hydrate Salt)


  • Catalogue No.:PA 13 0280021

  • CAS :

    1217459-90-9

  • Molecular Formula : C19H22N8O6

  • Molecular Weight : 458.44

stdClass Object
(
    [pname] => Diethyl (3-(methylamino)benzoyl)-L-glutamate
    [catalogue_number] => PA 13 0281030
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 336.39
    [form] => C17H24N2O5
    [cas] => 2820151-35-5
    [pslug] => 2820151-35-5-diethyl-3-methylamino-benzoyl-l-glutamate-pa130281030
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PA 13 0281030
PA 13 0281030

Diethyl (3-(methylamino)benzoyl)-L-glutamate


  • Catalogue No.:PA 13 0281030

  • CAS :

    2820151-35-5

  • Molecular Formula : C17H24N2O5

  • Molecular Weight : 336.39

stdClass Object
(
    [pname] => Diethyl (2-(methylamino)benzoyl)-L-glutamate
    [catalogue_number] => PA 13 0281031
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 336.39
    [form] => C17H24N2O5
    [cas] => 1029980-84-4
    [pslug] => 1029980-84-4-diethyl-2-methylamino-benzoyl-l-glutamate-pa130281031
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PA 13 0281031
PA 13 0281031

Diethyl (2-(methylamino)benzoyl)-L-glutamate


  • Catalogue No.:PA 13 0281031

  • CAS :

    1029980-84-4

  • Molecular Formula : C17H24N2O5

  • Molecular Weight : 336.39

stdClass Object
(
    [pname] => Methotrexate - Impurity K (Monosodium Salt)
    [catalogue_number] => PA 13 0280111
    [category_ids] => ,97,76,
    [chemical_name] => 
    [weight] => 289.24
    [form] => C12H14N2NaO5
    [cas] => 97772-96-8
    [pslug] => 97772-96-8-methotrexate-impurity-k-monosodium-salt-pa130280111
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PA 13 0280111
PA 13 0280111

Methotrexate - Impurity K (Monosodium Salt)


  • Catalogue No.:PA 13 0280111

  • CAS :

    97772-96-8

  • Molecular Formula : C12H14N2NaO5

  • Molecular Weight : 289.24

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