baricitinib
Baricitinib was approved in February of 2017 as a second-line orally administered treatment for moderate to severe active rheumatoid arthritis in adults, either as a monotherapy or when combined with methotrexate.Baricitinib is a selective and reversible Janus kinase 1 (JAK1) and 2 (JAK2) inhibitor. Janus kinases belong to the tyrosine protein kinase family and play an important role in the proinflammatory pathway signalling that is frequently over-activated in autoimmune disorders such as rheumatoid arthritis. Reference standards of Baricitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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[pname] => Baricitinib - API Standards
[catalogue_number] => PA 29 41000
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[weight] => 371.42
[form] => C16H17N7O2S
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Baricitinib - API Standards
Catalogue No.:PA 29 41000
Molecular Formula : C16H17N7O2S
Molecular Weight : 371.42
stdClass Object
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[pname] => 1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
[catalogue_number] => PA 29 0411017
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[weight] => 266.15
[form] => C13H23BN2O3
[cas] => 1029716-44-6
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1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Catalogue No.:PA 29 0411017
Molecular Formula : C13H23BN2O3
Molecular Weight : 266.15
stdClass Object
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[pname] => tert-Butyl 3-(cyanomethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate
[catalogue_number] => PA 29 0411018
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[weight] => 388.28
[form] => C19H29BN4O4
[cas] => 1153949-15-5
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tert-Butyl 3-(cyanomethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate
Catalogue No.:PA 29 0411018
Molecular Formula : C19H29BN4O4
Molecular Weight : 388.28
stdClass Object
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[pname] => (4-(1-(3-(Cyanomethyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl Pivalate
[catalogue_number] => PA 29 0411019
[category_ids] => ,71,78,70,82,88,
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[weight] => 393.45
[form] => C20H23N7O2
[cas] => 2102104-38-9
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(4-(1-(3-(Cyanomethyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl Pivalate
Catalogue No.:PA 29 0411019
Molecular Formula : C20H23N7O2
Molecular Weight : 393.45
stdClass Object
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[pname] => (4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl Pivalate
[catalogue_number] => PA 29 0411020
[category_ids] => ,71,78,70,82,88,
[chemical_name] =>
[weight] => 485.56
[form] => C22H27N7O4S
[cas] => 1187595-90-9
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(4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl Pivalate
Catalogue No.:PA 29 0411020
Molecular Formula : C22H27N7O4S
Molecular Weight : 485.56
