Atorvastatin – an oldest known statin drug

Published Oct 16, 2019 by pharmaffiliates
Atorvastatin – an Oldest known statin drug

A class of drugs that helps in lowering the cholesterol levels in the blood are known as Statins. By lowering these levels they help in preventing heart attack, stroke and other related cardiovascular diseases. Statins are competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) reductase – an enzyme involved in the production of cholesterol.

Atorvastatin is one of the oldest known drugs of statin class and is widely and extensively used in the prevention and treatment of cardiovascular diseases.

Atorvastatin was patented in 1986 and approved for medical use in the United States in 1996 and is available as a generic medication.

Atorvastatin is known to lower the levels of total blood cholesterol, low-density lipoprotein (LD, Apoprotein (Apo)-B, and triglycerides. LDL is also referred to as "bad" cholesterol and Apo B is a marker for cardiovascular risk. Atorvastatin also increases the levels of HDL cholesterol (good cholesterol).

The clinical dosage range for Atorvastatin is 10-80 mg/day, and it is given in the acid form.

Atorvastatin acid is highly soluble and permeable, and the drug is completely absorbed after oral administration. Atorvastatin acid is extensively metabolized in both the gut and liver by oxidation, lactonization, and glucuronidation, and the metabolites are eliminated by biliary secretion and direct secretion from blood to the intestine.

Atorvastatin acid

Atorvastatin Acid

CAS No - 134523-00-5

Product Code – PA 01 83000

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A total number of 87 impurities of Atorvastatin acid are available at Pharmaffiliates which includes all the known, unknown, in house impurities and Deuterium labeled compounds as well. This is one of the largest inventory of Atorvastatin acid impurities and related substances that is readily available under one single roof i.e at Pharmaffiliates.

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