High-Purity Pyrido[2,3-d]Pyrimidine Intermediate for Advanced Oncology Research
2-(8-Cyclopentyl-5-methyl-7-oxo-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)acetaldehyde (CAS 2204368-66-9)
Product Overview
2-(8-Cyclopentyl-5-methyl-7-oxo-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)acetaldehyde is a structurally complex heterocyclic aldehyde derivative widely recognized as a critical intermediate and impurity reference standard in the synthesis of CDK4/6 inhibitor–based oncology APIs.
Belonging to the pyrido[2,3-d]pyrimidine chemical class, this compound plays an important role in drug development, impurity profiling, and analytical method validation, particularly for kinase-targeted anticancer molecules.
Why This Compound Is Important in Pharmaceutical R & D
The presence of an acetaldehyde functional group combined with a piperazinyl-substituted pyridine moiety makes this compound chemically reactive and analytically significant. Such structures often emerge during multi-step synthesis and must be identified, characterized, and controlled to meet global regulatory expectations.
This compound is commonly used for:
- Impurity identification and qualification
- Analytical method development (HPLC, LC-MS, NMR)
- Stability and degradation pathway studies
- Reference standard applications in regulated laboratories
Regulatory & Quality Relevance
In line with ICH Q3A/Q3B guidelines, pharmaceutical manufacturers are required to monitor and control process-related and degradation impurities. 2-(8-Cyclopentyl-5-methyl-7-oxo-…acetaldehyde) serves as a well-characterized impurity standard, supporting:
- Accurate impurity quantification
- Robust API release testing
- Regulatory submissions and compliance
Its availability as a characterized reference material significantly reduces analytical uncertainty during drug development and lifecycle management.
Applications
- Oncology API development programs
- CDK inhibitor impurity profiling
- CRO and CDMO analytical laboratories
- Pharmaceutical R&D and regulatory studies
- Method validation and forced degradation studies
Why Choose Pharmaffiliates
Pharmaffiliates supplies high-purity pharmaceutical intermediates and impurity standards manufactured under stringent quality systems. Each material is supported with:
- Comprehensive Certificate of Analysis (CoA)
- Advanced spectral characterization
- Reliable batch-to-batch consistency
- Custom synthesis and scale-up support on request
Conclusion
2-(8-Cyclopentyl-5-methyl-7-oxo-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)acetaldehyde is an essential compound for high-precision pharmaceutical research, enabling accurate impurity control and regulatory-ready analytics for oncology drug development.
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