High-Purity Pharmaceutical Intermediates & Impurity Standards: Advancing Drug Discovery and Analytical Research
Pharmaceutical innovation depends on precision, purity, and reproducibility. High-purity intermediates, metabolites, and impurity standards are critical for ensuring the safety, efficacy, and regulatory compliance of drug candidates. They enable reliable stability testing, impurity profiling, pharmacokinetic studies, and analytical method validation, which are essential in modern drug discovery.
At Pharmaffiliates, we have spent over two decades supporting global pharmaceutical and biotech companies by providing authentic reference standards and specialty chemicals. Our ISO 17025-certified laboratories and validated analytical processes ensure that every compound delivered meets stringent quality requirements.
This catalog highlights a selection of compounds from our portfolio, each playing a pivotal role in drug discovery, medicinal chemistry, and analytical research.
Methyl Nicotinate (CAS 93-60-7)
Type: Nicotinate Ester / Pharmaceutical Intermediate
Significance: Methyl Nicotinate is widely used in dermatological and pharmacological research. Its nicotinate ester structure facilitates transdermal studies and functional skin metabolism assays.
Application: Supports topical drug formulation research, metabolic pathway studies, and analytical method development.
4-Hydroxyquinoline-3-carboxylic Acid (CAS 34785-11-0)
Type: Quinoline Derivative / Research Intermediate
Significance: Quinoline derivatives are foundational scaffolds in medicinal chemistry. This compound is particularly valuable for synthesizing antibacterial, antiviral, and anticancer candidates.
Application: Used in heterocyclic synthesis, impurity profiling, and pharmaceutical intermediate development.
3-Methylacetophenone (CAS 585-74-0)
Type: Aromatic Ketone / Fine Chemical
Significance: 3-Methylacetophenone is an essential aromatic ketone used in the synthesis of APIs and fine chemicals. Its structure allows for selective reactions in medicinal chemistry pathways.
Application: Supports synthetic route development, impurity analysis, and advanced intermediate production.
10-alpha-Hydroxy-Dextromethorphan (CAS 133443-97-7)
Type: Metabolite / Impurity Standard
Significance: A key metabolite of Dextromethorphan, this compound is vital in pharmacokinetic studies and metabolic pathway analysis.
Application: Used in drug metabolism research, impurity profiling, and reference standard validation for regulatory studies.
1-(1-Ethylpiperidin-3-yl)methanamine (CAS 102459-02-9)
Type: Piperidine Derivative / Pharmaceutical Intermediate
Significance: Piperidine derivatives are crucial scaffolds for CNS-active drugs and other therapeutic agents.
Application: Used in medicinal chemistry for API synthesis, impurity studies, and structural optimization in drug discovery.
Desfluoro-Citalopram (CAS 1026009-77-7)
Type: API Analog / Antidepressant Intermediate
Significance: An analog of Citalopram, Desfluoro-Citalopram is useful for developing novel antidepressant therapies and studying structure-activity relationships.
Application: Applied in synthetic pathway development, impurity profiling, and pharmacological testing.
Pheniramine Maleate Impurity C Freebase (CAS 109090-39-3)
Type: Pharmaceutical Impurity Standard
Significance: A recognized impurity of Pheniramine Maleate, this compound ensures accurate quality control and regulatory compliance.
Application: Used in stability studies, impurity profiling, and analytical method validation for antihistamines.
R-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-3-yl)propan-1-amine Oxalate (CAS 116817-26-6)
Type: Advanced Pharmaceutical Intermediate
Significance: A complex intermediate used in drug discovery, particularly for CNS-active molecules and heterocyclic derivatives.
Application: Supports synthetic chemistry research, impurity identification, and structural optimization in medicinal chemistry.
1-Piperidineethanol-d4 (CAS 1189705-44-9)
Type: Deuterated Standard / Analytical Reference
Significance: Deuterated compounds are essential for mass spectrometry, pharmacokinetic studies, and isotope labeling experiments.
Application: Used in quantitative analysis, analytical method development, and R&D studies for pharmaceutical research.
1-Allyl-2,6-methoxy-1H-benzo[d][1,2,3]triazole-5-carboxamido-methyl-pyrrolidine-1-oxide (CAS 1213268-38-2)
Type: Heterocyclic Intermediate / Research Chemical
Significance: Serves as a versatile heterocyclic scaffold for medicinal chemistry, supporting new drug discovery programs.
Application: Applied in API synthesis, impurity profiling, and advanced heterocyclic chemistry.
Pharmaffiliates Advantage: Supplied with complete analytical validation, ensuring reproducibility in synthetic and analytical workflows.
Why These Standards Matter
Each compound in this catalog strengthens drug development, analytical accuracy, and regulatory compliance. From metabolites like 10-alpha-Hydroxy-Dextromethorphan to deuterated standards such as 1-Piperidineethanol-d4, these chemicals enable:
- Accurate impurity profiling and method validation
- Reliable pharmacokinetic and metabolic studies
- Synthetic route optimization for novel drug candidates
- Regulatory compliance (ICH Q3, FDA, EMA guidelines)
By partnering with Pharmaffiliates, research organizations gain access to:
- High-purity intermediates, metabolites, and APIs
- ISO 17025-certified analytical support
- US FDA audited facilities
- Custom synthesis and global supply capabilities
- Compliance-ready documentation (COA, MSDS, NMR, HPLC)
For over 20 years, Pharmaffiliates has been a trusted partner in pharmaceutical innovation, helping companies worldwide meet stringent quality and regulatory expectations.
